Neuproscan

Alzheimer's diagnosis comes too late for most people, affecting both quality and expectancy of life. NeuProScan can identify Alzheimer’s years ahead using a single MRI scan.

Why an MRI Predictor for Alzheimer's is More Than Useful

Two newly approved drugs, Lecanemab and Aducanemab, slow Alzheimer's disease progression. They require, however, a positive amyloid PET scan, costing $5000.

Health systems face a challenge: an increase in PET scan demand could strain resources. MRI scans, cheaper at $1300, are initially used to assess eligibility for PET scans. However, MRIs have a high error rate in early Alzheimer's stages: 29% false positives and 27% false negatives.

NeuProScan helps doctors improve MRI diagnosis accuracy. This ensures more effective use of costly PET scans, benefiting both patients and healthcare systems.

The Results

• All of the patients below were diagnosed as Healthy by a doctor
• A third of those went on to develop Alzheimer’s in the next few years
• NeuProScan had correctly identified 88% of them as very likely to develop Alzheimer’s

Raw Data

NeuProScan is an easy-to-use, fully customizable AI platform, catering to both individual doctors and big hospitals. It takes in patient MRI scans and predicts their likelihood of developing Alzheimer's in the next few years. It can be run both on device or in the cloud, and it also allows the user to create their own custom AI models

Varying the Slices used for the model

Each MRI scan is made up of hundreds of slices. Each of these slices can give us data to use in our program. However, some slices are more important than others and have greater impact to the model's performance.

Consider it like this. If we imagine the slices being like a loaf of bread, there are three main views or sections we are interested in: sideways (axial), front to back (coronal), and left to right (sagittal).

We've come up with a clever way of choosing different slices to look at. This means our system can deal with a variety of different slice sets.

At the moment, our AI models use only up to 9 slices to make a prediction. These slices are selected automatically from the MRI scan. They can be from anywhere, but they usually come from the middle parts of the sideways, front-back, and left-right views. For each of these views, we can also add in 2 extra slices (one from each side of the middle). So in total, we can look at 9 slices all together.

Here you can find more about the currently deployed and active models

Read more about the performance metrics for the models

How does it compare